Evidence-led human genetics
Understanding the genetics of complex disease.
InsideGen is an expert-curated, evidence-based resource that explains what we currently know about the genetics and biology of complex diseases. Rather than aiming to catalogue every reported genetic association, we deliberately prioritise confidence over completeness. Our goal is to build a trusted resource where inclusion means confidence—if it's in InsideGen, it's because the weight of evidence supports it.
Explore InsideGen
Three routes into the evidence
Start with a disease, investigate a gene, or learn the concepts and methods that connect them.
Diseases
Explore what human genetics tells us about lupus and, over time, a growing range of complex diseases.
Lupus available nowGenes
Follow the evidence from genes and variants to the diseases, cells and biological pathways they influence.
TYK2 · IFIH1 · IRF5Education
Build a clear foundation in complex-disease genetics, from accessible disease guides to research methods.
Disease guides · MethodsFeatured disease
Resource availableSystemic lupus erythematosus
Explore the genetics of lupus—from heritability and association signals to candidate genes, shared biology and the questions researchers are still working to answer.
Explore lupus →- What is lupus?
- Genetics and heritability
- Genes and associated variants
- Shared genetics
- Research community
- Outstanding questions
Our mission
Make current knowledge understandable without losing scientific rigour.
InsideGen is an educational resource for researchers, clinicians, students, patients and the wider public. We interpret robust human-genetic evidence, explain how conclusions are reached, and distinguish established knowledge from emerging hypotheses.