Human genetics · Biology · Education

Understanding the genetics of complex disease.

InsideGen is an educational resource that explains the genetics and biology of complex diseases using evidence from human genetics research. Our goal is to make current knowledge accessible to researchers, clinicians, students, patients and the wider public.

Evidence-ledHuman genetics researchWritten forSpecialists and the public
DNA, immune biology and genetic data connected in an integrated research networkGenetics Biology Data integration

Complex disease needs a connected explanation.

Most common diseases are shaped by many genetic variants alongside environmental, behavioural and biological influences. InsideGen brings these layers together without losing sight of uncertainty, context or the people affected.

From evidence to understanding

01

Find genetic signals

Human genetics can reveal regions of the genome associated with disease susceptibility, severity and outcome.

02

Understand biology

Connecting genetic evidence to genes, cells and pathways helps explain the mechanisms underlying complex disease.

03

Make evidence accessible

Clear explanations and open resources help more people understand what current research can—and cannot—tell us.

Current disease resource

Systemic lupus erythematosus

Explore what human genetics has revealed about lupus susceptibility, immune biology and shared mechanisms, alongside research publications and data resources.

Additional complex-disease resources can be added here over time.
Regional genetic association plots comparing SLE and severe COVID-19

Our mission is to make the genetics of complex disease understandable and accessible, helping patients, researchers and the wider public explore what current evidence tells us about human disease.